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Explore Our Labs

Laboratory of Dr. Thomas Abrams

PhD student Allison Lin (MPET) stands by a low-pressure chromatography setup she uses to purify His-tagged recombinant proteins. She is studying calcium/ calmodulin-activated adenylyl cyclase from the brain and investigating the role that this signaling enzyme plays in learning and memory.


 

Laboratory of Dr. Edson Albuquerque

PhD student (MMED) Iusta Caminha, who is supervised by Dr. Edna Pereira, is shown at her electrophysiology setup analyzing whole-cell currents evoked from cultured hippocampal neurons. These experiments are part of her studies on cognitive effects caused by longterm use of selective estrogen receptor modulators, in particular tamoxifen.


 

Laboratory of Dr. Laure Aurelian

MD/PhD student Mike Gober (MPET) stands by his poster at the 2005 annual meeting of the International Union of Microbiological Societies (IUMS) in San Francisco, CA. His studies were also selected for oral presentation and won an award. They identify a strong and versatile anti-apoptotic gene and describe the development of a novel herpesvirus vector for its delivery to the CNS, which should help lead to gene therapy of neurodegenerative diseases.


 

Laboratory of Dr. Angela Brodie

PhD student Sean Vasaitis (MPET) presents his data on several potent new compounds with novel actions at a recent lab meeting. Sean found that they not only inhibit androgen synthesis but also degrade the androgen receptor. One of the compounds also markedly suppressed prostate tumor growth in animal models. These compounds thus have potential in treating prostate cancer.


 

Laboratory of Dr. Avi Gnatt

Dr. Avi Gnatt and his PhD student Kyle Hubbard (MPET) examine an ammonium sulfate precipitate containing mammalian RNA Polymerase II, in which Dr. Gnatt’s group has demonstrated a novel thirteenth subunit. The new subunit plays an important function in regulation of transcription. Kyle is exploring the role of transcription factors with RNA interference (RNAi), with the ultimate goal of developing novel cancer therapeutics.


 

Laboratory of Dr. Jessica Mong

PhD student Tamara Blutstein (NACS) shows Dr. Jessica Mong her data demonstrating the ability of estrogen to increase key glial and neuronal enzymes, glutamine synthetase and glutaminase, respectively, necessary for the production of the excitatory neurotransmitter glutamate.


 

Laboratory of Dr. Vincent Njar

PhD student Aakanksha Khandelwal (MMED), working in the lab of Dr. Vincent Njar, prepares to expose a Western blot aimed at determining modulation of proteins following treatment of human prostate cancer cells with novel agents designed and synthesized by the group. Such studies may provide insight into the mechanism of action of the new anti-cancer agents. Several compounds developed in Dr. Njar’s lab are in development for treatment of breast and prostate cancers.


 

Laboratory of Dr. Danny Weinreich

PhD student Jeannie Orlando (MPET) looks up from her experiment aimed at understanding how sensory nerves in the cornea regulate corneal epithelial growth and differentiation.